Heat oven to broil. Prepare pasta according to package directions.
In oven-safe large skillet, cook sausage until browned and crumbly; drain. Add ¼ cup pepperoni and cook 1 minute.
Add sauce, oregano, basil, and garlic powder in skillet and cook until heated. Add pasta and heat 1-2 minutes. Sprinkle cheese and remaining pepperoni; remove from heat.
Place into oven and broil 1-2 minutes until cheese is melted and golden.